Zbrush or Bust
I have probably fiddled with allot of software, 3ds Max being the major. Having tried a demo of Zbrush and watching a few video tutorials I was simply blown away with its power. Models that have taken me weeks to create using dcc apps were ready and painted in Zbrush in just a few minutes. Now that is power you can't beat, not to mention the cost the cost difference.
Zspheres is an ingenious idea, puts a cork in everything you know about traditional way of modeling.
1. Try the demo.
2. Look at the art and tutorials out there.
3. Question the market.
4. Make the move.